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Cholesterol Management >> Side Effects of Statin Drugs >> Gene Method
Drug Manufacturer Seeks to Lower Cholesterol Using Gene Method
Lower cholesterol may be more a matter of heredity than diet for millions of Americans. This knowledge is what led drug manufacturer, Isis Pharmaceuticals, to develop a new drug that interferes with a specific type of protein production that is involved in the manufacturing by the body of bad cholesterol.
The Low Density Lipoprotein (LDL) and Very Low Density Lipoprotein (VLDL) are the two types that are considered bad because they build up as a waxy plaque in the arteries, and can narrow the arteries making the patient more susceptible to stroke and heart disease. The drug, Isis 301012 as it is called at this stage of development, approaches reducing LDL and VLDL by a process known as antisense. This experimental genetic method prohibits the protein, ApoB100, which carries LDL through the blood from being made. The anitsense method actually stops the gene used to make LDL and VLDL from working.
In experiments to lower cholesterol with Isis 301012, results were promising. The LDL levels of participants fell between 27 and 44 percent after the 25-day trial period. The drug has also been shown to lower fat in the blood by more than 55 percent. It is believed at this point that Isis 301012 does not cause the same side effects many people get with statin drugs, such as the severe muscle soreness, but it is still in its experimental stages. Currently statin drugs are the most commonly prescribed cholesterol reducing drugs. They are sold under such brand names as Lipitor, Zocor, and Pravachol.
If you don’t like the idea of using an experimental drug to lower cholesterol, or the risk of known side effects, you can lower cholesterol naturally through diet and exercise. Specific minerals and herbs have been proven to safely and effectively lower cholesterol. The complete plan is outlined in The 60-Day Prescription Free Cholesterol Cure.
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