Cholesterol Management >> Effects of Cholesterol >> Tangier
Tangier Disease Add to Challenge to Reduce Cholesterol
It can be even more difficult to reduce cholesterol if you are one of the rare individuals with a recessive genetic condition called Tangier disease. People with Tangier have extremely low levels of good cholesterol, which is the High Density Lipoprotein (HDL) cholesterol. HDL helps reduce total cholesterol by cleansing the build up of Low Density Lipoprotein (LDL) cholesterol from the body. LDL cholesterol is also referred to as bad cholesterol.
The reason people with Tangier disease have low levels of HDL cholesterol is because of a mutation to the ABCA1 gene. Even though ABCA1 affects HDL production, it is unclear how this works and more research is needed exactly why it happens.
Tangier disease is a blood disorder that is hereditary. It can result in high cholesterol and circulation problems. It may even cause organs to become enlarged when large amounts of HDL cholesterol build up in them instead of doing their job in transporting LDL. Other names that are used synonymously for Tangier disease are Alpha High Density Lipoprotein Deficiency, Alphalipoproteinemia, Analphalipoproteinemia, Familial Alpha-Lipoprotein Deficiency, and Familial High-Density Lipoprotein Deficiency.
When trying to reduce cholesterol health care professionals will focus on lowering LDL and raising HDL in an effort to control total cholesterol. HDH cholesterol should be at least 40 mg/dL. Lower levels can lead to higher total cholesterol. Prescription drugs designed to raise HDL cholesterol are effective in reducing cholesterol, even for those with this generic disorder of the ABCA1 gene. However, all prescription drugs come with side effects that can be undesirable and even dangerous.
You can reduce cholesterol in two basic ways: lower your LDL and raise HDL cholesterol levels. A low fat, low cholesterol diet addresses the LDL cholesterol while exercise is critical to raising HDL. To learn more about reducing cholesterol naturally, you can get The 60-Day Prescription Free Cholesterol Cure.
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